Hla mus rau cov ntsiab lus

EB research projects

DEBRA UK yog qhov loj tshaj plaws UK pab nyiaj ntawm EB research, muab khoom plig rau cov kws tshawb fawb nrog cov kws tshaj lij hauv kev tshawb fawb thiab kev kho mob feem ntau cuam tshuam rau cov tsev neeg nyob nrog EB.

Peb cov ntaub ntawv ntawm cov haujlwm tshawb fawb suav nrog kev ua haujlwm hauv chaw kuaj mob preclinical, kev tshawb fawb txog noob caj noob ces thiab kev kho mob ntawm tes thiab kev siv tshuaj rov ua dua tshiab, nrog rau cov haujlwm uas ua rau muaj kev hloov pauv cov tsos mob rau kev kho mob thiab kho mob qog noj ntshav.

Cov kev tshawb fawb peb tau nyiaj yog cov hauv ntiaj teb no, thiab qhov ntawd yog vim peb tsis yog nyiaj txiag UK cov kws tshawb fawb thiab kws kho mob tab sis qhov zoo tshaj plaws hauv ntiaj teb. Ntau qhov haujlwm peb tau txais kev sib koom ua ke kev paub thiab kev txawj los ntawm cov kws tshawb fawb ntawm ntau qhov chaw tshawb fawb hauv UK thiab thoob ntiaj teb.

Ib tug neeg tuav lub stethoscope nyob ze ntawm lub ntsiav tshuaj uas qhia cov ntawv sau ntawm tes zaum ntawm lub laptop ntawm lub ntsej muag beige.

Thawj qhov chaw tshawb fawb EB hauv Africa

Dr Daudi Mavura, Regional Dermatology Training Center (RDTC), Tanzania
Xav paub ntau ntxiv
Ob tug neeg koom nrog hauv cov haujlwm tshawb fawb taw tes rau ntawm lub ntsiav tshuaj uas qhia cov kab ntawv DNA hauv xiav thiab daj. Ib tug neeg hnav lub tsho (lab).

Sequencing EBS noob

Dr Laura Valinotto, CEDIGEA, University of Buenos Aires, Argentina
Xav paub ntau ntxiv
Cov duab microscopic qhia cov kab mob ntshav qab zib kheej kheej ntawm cov xim ntsuab ntsuab.

Biofilms ncua EB qhov txhab kho

Dr Josefine Hirschfeld, University of Birmingham, UK
Xav paub ntau ntxiv
Piv txwv ntawm DNA strand interacting nrog hexagonal graphene nto, showcasing molecular kev sib cuam tshuam ntawm kab sib chaws keeb kwm.

Simplified genetic testing rau txhua hom EB

Dr Ene-Choo Tan, KK Women's and Children's Hospital, Singapore
Xav paub ntau ntxiv
Cov duab ntawm ob DNA strands nrog glowing xaus tiv thaiv keeb kwm yav dhau tsaus nti nrog faint gears thiab circuit designs.

CRISPR/Cas9 kho RDEB noob

Dr Sergio López-Manzaneda, CIEMAT, Spain
Xav paub ntau ntxiv
Daim duab qhia txog tus kab mob txhaj tshuaj genetic khoom mus rau hauv lub cell, qhia cov kab mob uas txuas thiab xa DNA los yog RNA mus rau hauv lub host cell.

Txhim kho kev xa khoom ntawm RDEB gene therapy

Dr Ángeles Mencía, CIEMAT, Spain
Xav paub ntau ntxiv
Daim duab tas luav ntawm ib txoj hlua DNA

Hickerson 2 (2019)

Dr Robyn Hickerson, University of Dundee, UK
Xav paub ntau ntxiv
Daim duab tas luav ntawm ib txoj hlua DNA

Hubbard 1 (2017)

Lynne Hubbard, St Thomas' Tsev Kho Mob, London, UK
Xav paub ntau ntxiv
Daim duab tas luav ntawm ib txoj hlua DNA

Liossi (2014)

Dr Christina Liossi, University of Southampton, UK
Xav paub ntau ntxiv
Ib tus kws tshawb fawb hauv lub tsho loj thiab cov hnab looj tes xiav siv lub raj xa dej sib txuas los hloov cov kua rau hauv microplate.

PhD: sib ntaus RDEB daim tawv nqaij mob cancer

Prof Gareth Inman, Cancer Research UK Scotland Institute, UK
Xav paub ntau ntxiv
Cov duab ntawm tus kab mob nrog lub plhaub sab nrauv thiab pom DNA qauv, qhia txog qhov nyuaj nyuaj uas tau ntsib hauv kev kho kab mob hauv txoj hlab ntsws, nyob ib puag ncig los ntawm cov kab mob zoo sib xws ntawm lub teeb tom qab.

PhD: mRNA therapy for JEB

Prof McCarthy, Poj huab tais University, Belfast
Xav paub ntau ntxiv
Piv txwv ntawm ib ntu ntawm tib neeg daim tawv nqaij, nrog rau cov txheej txheem pom, cov hauv paus plaub hau, cov hlab ntsha, thiab lub ntsej muag liab liab nyob ib puag ncig lub qhov txhab.

PhD: nce YAP / TAZ txhawm rau txhawm rau kho qhov txhab

Dr Gernot Walko, QMUL, UK
Xav paub ntau ntxiv
Kaw-up sab profile ntawm tus me nyuam pw tsaug zog, ntsia saum toj, nrog rau qhov muag thiab cov plaub muag ntev.

PhD: txo DEB / JEB qhov muag caws pliav

Prof Keith Martin, CERA, University of Melbourne, Australia
KAWM NTXIV
Ib tus kws tshawb fawb hnav hnab looj tes xiav tso Petri tais hauv qab lub tshuab tsom rau kev kuaj xyuas.

PhD: txo cov hlwv hauv JEB

Dr Emma Chambers, QMUL, UK
Xav paub ntau ntxiv
Ib tug neeg hauv hnab looj tes xiav siv lub pipette los hloov cov kua liab mus rau hauv ntau lub tais, nrog rau cov khoom siv hauv chav kuaj thiab cov thawv ntim hauv qab.

PhD: txhim kho daim tawv nqaij hauv JEB

Dr Emanuel Rognoni, QMUL, UK
Xav paub ntau ntxiv
Cov duab ntawm DNA strand interacting nrog ntsuab spherical molecules, teem tawm tsam gradient keeb kwm yav dhau.

PhD: nanoneedle qhov txhab kawm hauv RDEB

Prof John McGrath, KCL, UK
Xav paub ntau ntxiv
Daim duab qhia cov theem ntawm kev kho qhov txhab: txhaws nrog pob txuv tsim, cell multiplication, thiab cov ntaub so ntswg kho nrog ntshav. Cov ntawv sau muaj xws li epidermis, dermis, fibroblast, thiab macrophage.

PhD: Kev kho mob hauv txhua hom EB (2024)

Prof Adrian Heagerty thiab Dr Ajoy Bardhan, University of Birmingham, UK
Xav paub ntau ntxiv
Cov duab qhia ntxaws ntxaws qhia txog tib neeg lub caj dab nrog trachea, bronchi, thiab ib puag ncig cov hlab ntsha thiab cov hlab ntsha, qhia txog yuav ua li cas biofilms tuaj yeem ncua EB qhov txhab kho.

Kev kho mob rau cov kab mob hauv lub ntsws hauv JEB

Dr Robert Hynds, University College London, UK
Xav paub ntau ntxiv
Ib tug neeg nyob rau hauv lub tsho tiv no lab tuav lub koob txhaj tshuaj nrog rab koob poised upwards.

Repurposing dupilumab los kho khaus hauv txhua hom EB

Prof Amy Paller, Northwestern University, Tebchaws Asmeskas
Xav paub ntau ntxiv
Daim duab ntawm tus neeg tuav lub ntsiav tshuaj ntawm lawv txhais tes.

Psoriasis ntsiav tshuaj repurposed rau EBS

Dr Christine Chiaverini, Center Hospitalier Universitaire de Nice, Fab Kis teb
Xav paub ntau ntxiv
Ib phau ntawv, daim ntawv nplaum, thiab lub laptop nyob ze ntawm ib daim ntawv uas qhia cov kab kos duab thiab cov duab kos rau ntawm lub rooj.

Nyob nrog EB hauv UK

Dr Zoe Venables, University of East Anglia, UK
Xav paub ntau ntxiv
Ib tug menyuam yaus uas luag nyav hnav xiav npauj npaim tis tuav lub paj liab polka-dotted npauj npaim txiav tawm ntawm lub qhov rooj turquoise.

Kho JEB nrog laminin protein

Dr Matthew Caley, QMUL, UK
Xav paub ntau ntxiv
Ib tug menyuam yaus siv rab diav los saib rau hauv tus neeg laus lub qhov ncauj qhib. Ob leeg nyob hauv tsev, zaum ntawm lub rooj zaum.

DEB mob cancer thiab qhov ncauj qhov txhab kho

Dr Inês Sequeira, QMUL, UK
Xav paub ntau ntxiv
Tsib tus yuam sij keyboard sau "PASTE" teem rau ntawm keeb kwm liab.

Permanent gene therapy for DEB

Dr Joanna Jacków, KCL, UK
Xav paub ntau ntxiv
Tus kws muag tshuaj tshuaj xyuas ib lub raj mis tshuaj ntawm lub txee uas muaj ntau yam khoom siv tshuaj.

Repurposing statins rau RDEB daim tawv nqaij mob cancer

Dr Roland Zauner, EB House, Austria
Xav paub ntau ntxiv
Tsev neeg luag ntxhi ntawm lub koob yees duab. Ib tug tub hluas hnav lub tsho DEBRA liab qab

Cov cuab yeej muaj kev noj qab haus huv rau txhua tus niam txiv EB

Prof Andrew Thompson, Cardiff University, UK
Xav paub ntau ntxiv
Ib tug ze-up ntawm tus me nyuam ko taw so ntawm tus neeg laus txhais tes nrog dub-painted rau tes, teem tiv thaiv ib tug mos mos, qhov muag plooj tom qab.

Kev kho mob hlwv zoo rau EBS

Prof John Connelly, QMUL, UK
Xav paub ntau ntxiv
Kaw ntawm ib lub qhov muag nrog ib tug xim av iris, ntev plaub muag, thiab ib tug reflection ntawm lub teeb ntawm cov tub kawm ntawv.

Qhov muag dauv rau txhua hom EB

Prof Liam Grover, University of Birmingham, UK
Xav paub ntau ntxiv
Tus neeg tuav lub pob tshab 96-zoo phaj uas muaj ntau cov kua xim hauv chav kuaj.

Kev tshuaj ntsuam xyuas tshuaj rau lub hom phiaj RDEB mob qog noj ntshav

Prof Gareth Inman, CRUK Scotland Institute, UK
Xav paub ntau ntxiv
Daim duab qhia txog tus neeg mob-tsav cov thawj coj los tshawb fawb cov tshuaj cannabinoid-raws li tshuaj rau qhov mob thiab khaus hauv EB, muaj lub hlwb, tawv nqaij, thiab nplooj cannabis nrog rau PhD kev mob siab rau kev txhim kho daim tawv nqaij hauv JEB.

Kev kho Cannabinoid rau txhua qhov mob EB thiab khaus

Prof Dr André Wolff thiab Dr Marieke Bolling, University Medical Center Groningen, Netherlands
Xav paub ntau ntxiv
Piv txwv ntawm ib tug neeg uas muaj tshav kub kub ntawm lawv nraub qaum, sawv hauv qab hnub ci. Daim tawv nqaij qhia txog cov qauv hexagonal, hais txog lub hnub raug thiab cov nyhuv tshav kub.

KEB and skin cancer (2024)

Prof Valerie Brunton, University of Edinburgh, UK
Xav paub ntau ntxiv

Repurposing anti-scarring tshuaj nyob rau hauv RDEB (2023)

Dr Daniele Castiglia, Istituto Dermopatico dell'Immacolata, IRCCS, Ltalis
Xav paub ntau ntxiv
Daim duab ntawm ib tug txiv neej nrog ib qho chaw tseem ceeb uas qhia txog squamous cell carcinoma ntawm nws lub hauv pliaj thiab qhov ze ntawm daim tawv nqaij.

RDEB daim tawv nqaij mob cancer (2023)

Prof Gareth Inman, University of Glasgow, UK
Xav paub ntau ntxiv

Scarring in RDEB (2023)

Prof Giovanna Zambruno, Bambino Gesù Tsev Kho Mob Me Nyuam Me (IRCCS), Rome, Ltalis
Xav paub ntau ntxiv

Nkag siab txog kab mob ntawm txoj hlab ntsws hauv JEB (2023)

Dr Colin Butler, GOSH, UK
Xav paub ntau ntxiv

Kev koom tes hauv lub cev tiv thaiv kab mob hauv RDEB (2023)

Dr Yanling Liao, NYMC, USA
Xav paub ntau ntxiv

Daim tawv nqaij microbiome ntawm txhua hom EB (2023)

Prof Iain Chapple, Birmingham Dental School thiab Tsev Kho Mob, UK
Xav paub ntau ntxiv

Txau ntawm RDEB gene therapy (2022)

Dr Su Lwin, KCL, UK
Xav paub ntau ntxiv

PEBLES RDEB Symptom Study (2022)

Prof Jemima Mellerio, St John's Institute of Dermatology thiab GOSH, London
Xav paub ntau ntxiv

Taug kev nrog EBS (2022)

Dr Deborah Falla thiab Prof Adrian Heagerty, University of Birmingham, UK
Xav paub ntau ntxiv

Kev kho qhov ncauj / caj pas (2022)

Prof Liam Grover, University of Birmingham, UK
Xav paub ntau ntxiv

Rigosertib rau RDEB SSC (2022)

Dr Andrew South, Thomas Jefferson University, USA
Xav paub ntau ntxiv

Immune system cells thiab RDEB qhov txhab (2022)

Prof Dr Sabine Eming, University Hospital of Cologne, Lub teb chaws Yelemees
Xav paub ntau ntxiv

Kho DEB khaus nrog qia hlwb (2022)

Prof John McGrath thiab Prof Jemima Mellerio, KCL, UK
Xav paub ntau ntxiv

Gene therapy rau EBS thiab RDEB (2022)

Dr Robyn Hickerson thiab Dr Peter van den Akker, University of Dundee, UK
Xav paub ntau ntxiv

Decorin gel los txo cov caws pliav (2019)

Dr Mark de Souza thiab Prof Jean Tang, FIBRX Derm Inc, USA
Xav paub ntau ntxiv

LENTICOL F (2019)

Prof John McGrath, St John's Institute of Dermatology thiab Institute of Child Health, UK
Xav paub ntau ntxiv

Inman-South 1 (2019)

Dr Gareth Inman thiab Dr Andrew South, University of Dundee, UK
Xav paub ntau ntxiv

Hickerson 1 (2019)

Dr Robyn Hickerson, University of Dundee, UK
Xav paub ntau ntxiv

McLean 12 (2019)

Professor Irwin McLean thiab Dr Robyn Hickerson, University of Dundee, UK
Xav paub ntau ntxiv

Brunton 1 (2018)

Prof Valerie Brunton, University of Edinburgh, UK
Xav paub ntau ntxiv

ADSTEM (2018)

Prof John McGrath, St John's Institute of Dermatology, UK
Xav paub ntau ntxiv

Lub Plaub Hlis 2 (2017)

Dr Derry Roopenian, Jackson Laboratory, USA
Xav paub ntau ntxiv

Plaub Hlis 3 (2017)

Prof Jakub Tolar, University of Minnesota, USA
Xav paub ntau ntxiv

Plaub Hlis 2 (2017)

Dr Cedric Gaggioli, ADSM, Nice, France
Xav paub ntau ntxiv

Bauer 5 (2017)

Prof Johann Bauer, EB House, Austria
Xav paub ntau ntxiv

Lub Ib Hlis 1 (2017)

Prof Jouni Uitto, Thomas Jefferson University, USA
Xav paub ntau ntxiv

O'Toole (2015)

Prof Edel O'Toole, QMUL, UK
Xav paub ntau ntxiv

IBSTEM (2015)

Prof John McGrath, St John's Institute of Dermatology, UK
Xav paub ntau ntxiv

Plaub Hlis 2 (2015)

Prof Jakub Tolar, University of Minnesota, USA
Xav paub ntau ntxiv

McLean/Heagerty 1 (2014)

Prof Irwin Mclean thiab Prof Adrian Heagerty, University of Dundee, UK
Xav paub ntau ntxiv

McGrath (2014)

Prof John McGrath, Guy's Hospital London, UK
Xav paub ntau ntxiv

Sonnenberg (2013)

Dr Arnoud Sonnenberg, Lub Tsev Kawm Ntawv Kho Mob Netherlands, Netherlands
Xav paub ntau ntxiv

South (2013)

Dr Andrew South, Thomas Jefferson University, USA
Xav paub ntau ntxiv
Lub tsev niaj hnub, ntau zaj dab neeg nrog lub iav façade thiab kos npe nyeem "Cancer Research Building." Muaj cov nyom nyom nyob rau pem hauv ntej thiab ob peb tus neeg nyob ze ntawm qhov nkag.

Kev koom tes: RDEB ua ntej kho mob qog noj ntshav qauv

Prof Gareth Inman, CRUK Scotland Institute, UK
Xav paub ntau ntxiv
Xiav square nrog "NHS" nyob rau hauv cov tsiaj ntawv dawb, muab tso rau ntawm ib tug tsaus xiav tom qab.

NHS England Partnership: Nkag siab EB cov ntaub ntawv tus neeg mob nyob hauv NHS

Dr Zoe Venables thiab Marta Kwiatkowska, NHS England, UK
Xav paub ntau ntxiv